arcserve 12.5
protecting a few file servers 2 sql and 1 exchange and 1 unix box
the new backup exec does dedupe now.
if you are looking at a professional backup to disk setup then have a look at the HP D2D products, they offer dedupe, or a VLS (virtual library system) offers a virtual tape library offering disk backup speeds with dedupe and infinite incrementals if you use a decent backup software like netbackup or hp data protector.
you still need to back it off to tape though to get it offsite obviously, people seem to be so concerned about getting rid of tape, but its still massively important unless you have a second site to pipe it to or use one of these online 'cloud' backup companies.
lto 5 is due out now and thats faster than any system can pump data to it, its too fast, people think tape is slow but its sooooo fast now and being able to hold 3tb odd per tape is quite impressive.
the downside is restore times, so a lot of people snapshot data during the day using something like a netapp san and then you can restore very quickly from that and if you lose a site go to the tape restore.
Or better still use something like vmware at 2 site and SRM (site recovery manager) to failover the whole site in the event of a disaster, thats very cool technology.