Finished this last night after 102 hours, and my main thought was disapointment.
I'll try not to give away too many spoilers, but I tried to side with the NCR, but because of a bug I couldnt go any further with one of the quests (couldn't get a NPC to talk to me/give me correct dialogue) so ended up going independent.
It is a very good game, I loved everything apart from the main quest line!!! It was too muddled, I never really had a clue who I was doing stuff for, as there was the same objective in different quests. Oh, and by the time I'd got all the cool weapons I was level 30 and had already killed most of the hard stuff!
My favorite weapons: AM rifle, Sniper with carbon parts and Silencer, Balistic fist (ace!), Diana, Mercy, Ratcatcher (very good early in game), This Machine, Brush Gun. Together with power armour and Boone, I'm unstoppable
I'll keep this for the time being and wait for DLC expansions now....