SO, I had this problem with my clio a few years back. Im going off memory so bare with me here:
As said above, its going to be one of the following: Compression, Spark Plugs, Coil Pack, HT Leads or Injectors.
Injectors - You need to test the resistance across them. Multimeter time! Youtube is good for tutorials on these and a wuick search on here will show you what they should read.
HT Leads - Whip them off and check with a multimeter for continuity. Good guides for this on youtube.
Coil Pack - Not a scooby how to test these. Theyre cheap to replace if you get that far.
Spark Plugs - Again, quite cheap and might aswell replace them, never going to hurt.
Compression - Arguably the hardest to determine as most people dont have a compression tester laying about. I would personally attack this one last as its also going to be the most costly to repair if it is compression.
9 times out of ten (from what I can gather on this forum and it was true in my case) its going to be injectors. I tested the resistance across mine and they were fine. Well, they werent as a replacement set sorted it. IRRC theyre about £120 for a set. DO NOT buy anything other an OEM renault ones as the cheap chinese copies are usually junk - trust me on this.
Code reading is a definite help. It will tell you what the code is and which cylinder it is too. A quick help is to switch injectors around to see if the misfire moves. Same goes with HT leads but make sure they correspond to the correct hole in the coil pack or else the car will be firing in a very weird order. Sounds very bad, trust me.
Good luck