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My mate has a 335i m sport coupe. Took the Bridgestone runflats off for a set of Vredestein Ultrac Sessantas. The ride, handerling and grip where all greatly improved whilst the tyre noise and wear went down. BMW didn't care and the warranty on the car wasn't effected in his case.
Dads just changed his x5 from Bridgestone (iirc) runflats to conti sports and he can't believe the difference, The only real advantage to runflats is if the police are chasing you and have stingers!