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At first glance that looks like noise destroying the finer details of the shot to me.Have you tried a long exposure with as lower ISO as possible to see if it's still occurring? If so, it's very likely it could be a sensor issue as others have said or fingers crossed just dirt on the sensor.
The 5DII has an option (hidden in a sub menu) to map out dust and hot pixels from the sensor. If you give it a Google then you will get the guide on how to do it.
That might help, otherwise, lock the shutter open (also a hidden sub menu option) and check the sensor for visible dust.
If you can see it, then either take a brave pill and clean it yourself, or find a recommended camera shop that will do it for you.
Just done a long exposure with the lens cap on and it's rediculas how many coloured pixels show. Green, blue, red & white. Fully zoomed in and there is atleast 3 where ever I'm zoomed in on the picture.
If I stay zoomed in on a red dot for example in one spot and scroll to the next picture - depending on the colours in the picture it's still there, especially in dark colours, but in some colours were you should still be able to see it, it's totally vanished.
Iv chose to clean the shutter on the menu and taken the same photo again with the lens cap on but it's no different.
Looks like Iv had it a while but only noticed it since taking these night shots - first time with this 5dii
A friend thinks there "stuck" pixels that can be removed rather than "dead" pixels.