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Absolutely sod all at the moment, I have been having an issue with my normal anti-virus recently, where it seems to slow my boot time up by a long time so I'm going Rambo for the time being.
Usually though, I use Nod32 for my antivirus, and then just ad-aware + spybot for spyware. Never bothered with a software firewall, but if i was to use one, it would most likely be outpost.
I use common sense - and hijackThis just to make sure nothing has sneaked on (once very 3 months) - no anti-virus - no adware crap - no defrag s**t, no software firewall - sod all.